"They, then, who, amidst the lights of nature, do not know God, or the distinctions of right and wrong, or that they have a soul which is immortal and responsible, are guilty for that ignorance. To be ignorant of these things is sin, because such ignorance is vincible."
First, God exercises His sovereignty over the human intellect, even by the lights of nature. There is in the natural world a manifestation of God which lays all men under the obligation of knowing Him. They who,with the lights of nature before them, remain in ignorance of God, are not only intellectually in error, they are also morally in error, and they are responsible for that moral error. Not to know God is sin.
The Apostle says to the Romans; The invisible things of Him; that is, of God; from the creation of the world, are clearly seen,being understood by the things that are made, His eternal power also and divinity; so that they are inexcusable. Because that, when they had known God, they have not glorified Him as God, nor gave thanks; but became vain in their thoughts, and their foolish heart was darkened. For professing themselves to be wise, they became fools. And they changed the glory of the incorruptible God into the likeness of the image of a corruptible man. Here, then, is an express declaration,that the lights of nature are sufficient to prove to us the existence of God, His power, His Divinity, and, therefore, (Rom, i. 20-23.) his perfections; so that they are inexcusable who do not know God, and, therefore, do not believe and make an act of faith in Him, and of submission to His sovereignty, as their Maker and Lord...
They, then, who, amidst the lights of nature, do not know God,or the distinctions of right and wrong, or that they have a soul which is immortal and responsible, are guilty for that ignorance. To be ignorant of these things is sin, because such ignorance is vincible. The lights of nature are sufficient to prove these things, and they who are ignorant of them are willingly ignorant of them; that is, ignorant through their own will, and therefore culpable before God; and for that culpable ignorance will have to give account at the last day. (Henry Cardinal Manning, ‘The Fourfold Sovereignty of God’)